Blogs

Basics & Orientation — What exactly are bone marrow diagnostics? Part 1

Date: December 2, 2025

Author: PathCircle

Authors: Jacek Lesinski and Sabine Haase Imagine the following scenario: You sit down to review yet another peripheral smear, expecting the usual. But then, you notice something exciting: 2 blasts, some...

Eosinophils -“Stormchasers of the Immune System”

Date: November 12, 2025

Author: PathCircle

Eosinophils, the silent yet paradoxical warriors of our immune system. Originally designed to combat parasitic infections, these cells have now emerged as key players, and sometimes culprits in allergic disorders....

Leucoerythroblastic Blood Picture: A Diagnostic Window into Bone Marrow Pathology

Date: September 16, 2025

Author: Dr. Gayathri Talapula

A leucoerythroblastic blood picture (LEBP) represents an important hematological finding suggesting bone marrow infiltration or marked stress. The blood picture mainly consists of nucleated red blood cells (NRBCs), immature myeloid...

A Day In The Life Of A Pathologist: A Tale of Blood, Biopsies, and some occasional Coffee Spills

Date: August 21, 2025

Author: Dr. Gayathri Talapula

Pathology may sound like a world of microscopes and medical jargon, but at its heart, it’s about everyday people making sense of life’s mysteries through science. In this narrative, Dr....

Infectious Mononucleosis — The Enigma of Mononucleosis Syndrome

Date: July 22, 2025

Author: Dr. Saumil Sanghavi

Infectious mononucleosis (IM), commonly caused by Epstein–Barr virus (EBV), presents with fever, sore throat, lymphadenopathy, and fatigue. It is typically self-limiting but may lead to complications like splenic rupture or...

Colorful Hematology: How stains reveal cellular morphology

Date: July 1, 2025

Author: Jacek Lesinski

In modern hematology, advanced diagnostic methods such as flow cytometry, cytogenetics, and molecular diagnostics are increasingly replacing traditional stains. While these methods offer high specificity and sensitivity, cytochemical stains remain...

Uncovering a rare case of Acute Monocytic Leukemia: Can you spot the promonocytes in a blood smear?

Date: June 2, 2025

Author: Dr. Chaitra C, M.D. Pathology

Acute monocytic leukemia is a rare and aggressive subtype of acute myeloid leukemia with monocytic differentiation. Accurate identification of promonocytes as blast equivalents and their inclusion in the blast count...

Caught in the bloodline: unraveling Thalassemia

Date: May 16, 2025

Author: Dr. Sharitha Naganna, M.D. Pathology

Thalassemia is the most common genetic and hereditary blood disorder affecting the global population. It is caused by unbalanced production of globin chains, leading to ineffective erythropoiesis. It is prevalent...

Beyond the hairy cells: Decoding hairy cell leukemia

Date: May 1, 2025

Author: Dr. Pavithra Devi. N, M.D. Pathology

Hairy cell leukemia(HCL) is a type of chronic lymphoproliferative disorder (CLPD) and a neoplasm of the mutant mature memory B cells. It occurs in middle-aged to elderly individuals with a...

The ticking time bomb: Understanding acute promyelocytic leukemia from a pathologist’s lens

Date: April 15, 2025

Author: Dr. Gayathri Talapula, M.D. Pathology

Acute Promyelocytic Leukemia(APL) is a highly curable and distinct variant of acute myeloid leukemia, caused by t(15;17) translocation leading to the generation of the PML-RARA fusion protein. Early treatment with...